Szilard被迫回到布达佩斯从1918年可怕的西班牙流感中恢复过来，从未见过战斗。战争结束后，他短暂回到布达佩斯的学校，但于1920年转学到德国夏洛滕堡的Technische Hochschule。他很快就改变了学校和专业，在柏林洪堡大学学习物理，在那里他参加了讲座。比阿尔伯特爱因斯坦，马克斯普朗克和马克斯冯劳厄。获得博士学位后Szilard于1922年在柏林大学获得物理学博士学位，在理论物理研究所担任冯劳厄的研究助理，在那里他与爱因斯坦合作开发了基于革命性爱因斯坦 – 西拉德泵的家用冰箱。 1927年，Szilard被聘为柏林大学的讲师。正是在那里，他发表了他的论文“关于通过干预智能生物在热力学系统中减少熵”，这将成为他后来关于热力学第二定律的工作的基础。面对纳粹党反犹太主义政策的威胁和对犹太学者的严厉待遇，西拉德于1933年离开德国。在维也纳短暂居住后，他于1934年抵达伦敦。在伦敦圣巴塞洛缪医院试验连锁反应，他发现了一种分离碘放射性同位素的方法。这项研究使Szilard在1936年获得了第一项创建核链反应方法的专利。随着与德国的战争越来越可能，他的专利被委托给英国海军部以确保其秘密。
Szilard was forced to return to Budapest to recover from the terrible Spanish flu of 1918 and had never seen a fight. After the war, he briefly returned to the school in Budapest, but in 1920 transferred to the Technische Hochschule in Charlottenburg, Germany. He quickly changed his school and major, studying physics at Humboldt University in Berlin, where he attended lectures. Than Albert Einstein, Max Planck and Max von Laue. After receiving his Ph.D., Szilard received his Ph.D. in Physics from the University of Berlin in 1922 and was a research assistant at the Institute of Theoretical Physics as a research assistant at the Institute of Theoretical Physics, where he worked with Einstein to develop a revolutionary Einstein-Silard pump. Household refrigerator. In 1927, Szilard was hired as a lecturer at the University of Berlin. It was there that he published his paper “On the reduction of entropy in thermodynamic systems by interfering with intelligent organisms”, which would be the basis for his later work on the second law of thermodynamics. In the face of the threat of anti-Semitism policies of the Nazis and the harsh treatment of Jewish scholars, Silad left Germany in 1933. After a short stay in Vienna, he arrived in London in 1934. In a chain reaction at the St. Bartholomew Hospital in London, he discovered a method for isolating radioactive isotopes of iodine. This study led Szilard to obtain the first patent to create a nuclear chain reaction method in 1936. As the war with Germany became more and more likely, his patent was entrusted to the British Admiralty to ensure its secret.