皮肤主要由两层组成：最上层，表皮，作为对环境的屏障;和真皮层，表皮下的层占皮肤的90％。真皮还含有蛋白质胶原蛋白和弹性蛋白，这有助于赋予肌肤机械结构和柔韧性。人造皮肤的作用是因为它们关闭伤口，防止细菌感染和水分流失，并帮助受损皮肤痊愈。例如，一种常用的人造皮肤Integra由硅树脂制成的“表皮”和防止细菌感染和水分流失，以及基于牛胶原蛋白和糖胺聚糖的“真皮”组成。 Integra“真皮”起细胞外基质的作用 – 在细胞间发现的有助于调节细胞行为的结构支持 – 通过促进细胞生长和胶原合成诱导新的真皮形成。 Integra“真皮”也可生物降解，被新的真皮吸收和替代。几周后，医生用患者身体另一部分的表皮薄层代替硅树脂“表皮”。
Skin is primarily made of two layers: the uppermost layer, the epidermis, which serves as a barrier against the environment; and the dermis, the layer below the epidermis which makes up roughly 90 percent of the skin. The dermis also contains the proteins collagen and elastin, which help give the skin its mechanical structure and flexibility. Artificial skins work because they close wounds, which prevents bacterial infection and water loss and helps the damaged skin to heal. For example, one commonly used artificial skin, Integra, consists of an “epidermis” made of silicone and prevents bacterial infection and water loss, and a “dermis” based on bovine collagen and glycosaminoglycan. The Integra “dermis” functions as an extracellular matrix – a structural support found between cells that helps regulate cell behavior – that induces a new dermis to form by promoting cell growth and collagen synthesis. The Integra “dermis” is also biodegradable and is absorbed and replaced by the new dermis. After several weeks, physicians replace the silicone “epidermis” with a thin layer of epidermis from another part of the patient’s body.